Join the #1 community for gun owners of the Southwest
We believe the 2nd Amendment is best defended through grass-roots organization, education, and advocacy centered around individual gun owners. It is our mission to encourage, organize, and support these efforts throughout Arizona, Nevada, Utah, Colorado, and New Mexico.
Discuss firearms and all aspects of firearm ownership
Join others in organizing against anti-gun legislation
Find nearby gun shops, ranges, training, and other resources
Discover free outdoor shooting areas
Stay up to date on firearm-related events
Share photos and video with other members
...and much more!
Toll-like receptor 6 is a protein that in humans is encoded by the TLR6 gene. TLR6 is a transmembrane protein, member of toll-like receptor family, which belongs to the pattern recognition receptor (PRR) family. TLR6 acts in a heterodimer form with toll-like receptor 2 (TLR2). Its ligands include multiple diacyl lipopeptides derived from gram-positive bacteria and mycoplasma and several fungal cell wall saccharides. After dimerizing with TLR2, the NF-κB intracellular signalling pathway is activated, leading to a pro-inflammatory cytokine production and activation of innate immune response. TLR6 has also been designated as CD286 (cluster of differentiation 286).