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We believe the 2nd Amendment is best defended through grass-roots organization, education, and advocacy centered around individual gun owners. It is our mission to encourage, organize, and support these efforts throughout Arizona, Nevada, Utah, Colorado, and New Mexico.
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Toll-like receptor 4 is a protein that in humans is encoded by the TLR4 gene. TLR4 is a transmembrane protein, member of the toll-like receptor family, which belongs to the pattern recognition receptor (PRR) family. Its activation leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system.TRL4 expressing cells are myeloid (erythrocytes, granulocytes, macrophages) rather than lymphoid (T-cells, B-cells, NK cells). Most myeloid cells also express high levels of CD14, which facilitates activation of TLR4 by LPS.It is most well known for recognizing lipopolysaccharide (LPS), a component present in many Gram-negative bacteria (e.g. Neisseria spp.) and selected Gram-positive bacteria. Its ligands also include several viral proteins, polysaccharide, and a variety of endogenous proteins such as low-density lipoprotein, beta-defensins, and heat shock protein. Palmitic acid is also a TLR4 agonist.TLR4 has also been designated as CD284 (cluster of differentiation 284). The molecular weight of TLR4 is approximately 95 kDa.
S&W M&P 40
$450 without TLR-4
$500 with TLR-4
Custom OTW Kydex Holster can be included. It is fitted to accommodate the TLR-4
Comes with Standard 2 Magazines, do have 4 additional for purchase
Like New Original box & Paperwork
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