Join the #1 community for gun owners of the Southwest
We believe the 2nd Amendment is best defended through grass-roots organization, education, and advocacy centered around individual gun owners. It is our mission to encourage, organize, and support these efforts throughout Arizona, Nevada, Utah, Colorado, and New Mexico.
Discuss firearms and all aspects of firearm ownership
Join others in organizing against anti-gun legislation
Find nearby gun shops, ranges, training, and other resources
Discover free outdoor shooting areas
Stay up to date on firearm-related events
Share photos and video with other members
...and much more!
Toll-like receptor 4 is a protein that in humans is encoded by the TLR4 gene. TLR4 is a transmembrane protein, member of the toll-like receptor family, which belongs to the pattern recognition receptor (PRR) family. Its activation leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system.TRL4 expressing cells are myeloid (erythrocytes, granulocytes, macrophages) rather than lymphoid (T-cells, B-cells, NK cells). Most myeloid cells also express high levels of CD14, which facilitates activation of TLR4 by LPS.It is most well known for recognizing lipopolysaccharide (LPS), a component present in many Gram-negative bacteria (e.g. Neisseria spp.) and selected Gram-positive bacteria. Its ligands also include several viral proteins, polysaccharide, and a variety of endogenous proteins such as low-density lipoprotein, beta-defensins, and heat shock protein. Palmitic acid is also a TLR4 agonist.TLR4 has also been designated as CD284 (cluster of differentiation 284). The molecular weight of TLR4 is approximately 95 kDa.
S&W M&P 40
$450 without TLR-4
$500 with TLR-4
Custom OTW Kydex Holster can be included. It is fitted to accommodate the TLR-4
Comes with Standard 2 Magazines, do have 4 additional for purchase
Like New Original box & Paperwork
Thank you for viewing.