The SIG Sauer P250 is a semi-automatic pistol made by Sigarms (now known as Sig Sauer Inc. of Exeter, New Hampshire). Introduced in 2007 the SIG P250 can be chambered in .22 Long Rifle, .380 ACP, 9×19mm Parabellum, .357 SIG, .40 S&W, and .45 ACP. The P250 chambered in 9×19mm Parabellum was introduced to the North American market on November 7, 2007 followed by the .45 ACP compact model in February 2008 at the SHOT Show. The last of the models were introduced in late 2009.
In early 2014, the SIG P320 was introduced. This striker version of the P250 continues the modular format and shares several of the same components as its hammer-fired sibling including magazines and grip frames.
As of January 25, 2017, the only available caliber for the P250 on both the SIG Sauer website and their online catalog is the P250-22 Nitron Compact .22 Long Rifle. Exchange kits can convert the P250 from .22 Long Rifle to 9mm, .357 SIG, .40 S&W and .45 ACP.

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