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A centerfire cartridge is a firearm metallic cartridge whose primer is located at the centre of the base of its casing (i.e. "case head"). Unlike rimfire cartridges, the centrefire primer is typically a separate component seated into a recessed cavity (known as the primer pocket) in the case head, and is replaceable by reloading.
Centerfire cartridges have supplanted the rimfire variety in all but the smallest cartridge sizes. The majority of today's handguns, rifles, and shotguns use centrefire ammunition, with the exception of a few .17 caliber, .20 caliber, and .22 caliber handgun and rifle cartridges, small-bore shotgun shells (intended for pest control), and a handful of antique (and mostly obsolete) cartridges.

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