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Highway 22 (AR 22, Ark. 22, and Hwy. 22) is an east–west state highway in the Arkansas River Valley. It is maintained by the Arkansas State Highway and Transportation Department (AHTD). The highway runs 75.60 miles (121.67 km) from US 64/US 71B east to Highway 7 in Dardanelle. Following the historic stagecoach line of the cross-country Butterfield Trail, the highway is one of the original 1926 state highways. It is designated by the AHTD as the True Grit Trail.

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