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The .25-06 Remington had been a wildcat cartridge for half a century before being standardized by Remington in 1969. It is based on the .30-06 Springfield cartridge necked-down (case opening made narrower) to .257 caliber with no other changes. Nominal bullet diameter is 0.257 inches (6.5 mm), with typical bullet weights ranging from 75 to 120 grains (4.9 to 7.8 g). The bore diameter of the .25-06 Rem is .250 inches (6.35 mm) making it a ".25"/6.35 mm caliber", not to be confused with the more well known 6.5 mm bore caliber which uses 6.7 mm/.264" bullets.

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