Join the #1 community for gun owners of the Southwest
We believe the 2nd Amendment is best defended through grass-roots organization, education, and advocacy centered around individual gun owners. It is our mission to encourage, organize, and support these efforts throughout Arizona, Nevada, Utah, Colorado, and New Mexico.
Discuss firearms and all aspects of firearm ownership
Join others in organizing against anti-gun legislation
Buy, sell, and trade in our classified section
Find nearby gun shops, ranges, training, and other resources
Discover free outdoor shooting areas
Stay up to date on firearm-related events
Share photos and video with other members
...and much more!
G12/G13 alpha subunits are alpha subunits of heterotrimeric G proteins that link cell surface G protein-coupled receptors primarily to guanine nucleotide exchange factors for the Rho small GTPases to regulate the actin cytoskeleton. Together, these two proteins comprise one of the four classes of G protein alpha subunits. G protein alpha subunits bind to guanine nucleotides and function in a regulatory cycle, and are active when bound to GTP but inactive and associated with the G beta-gamma complex when bound to GDP. G12/G13 are not targets of pertussis toxin or cholera toxin, as are other classes of G protein alpha subunits.G proteins G12 and G13 regulate actin cytoskeletal remodeling in cells during movement and migration, including cancer cell metastasis. G13 is also essential for receptor tyrosine kinase-induced migration of fibroblast and endothelial cells.
Super rare and coveted by those that are in the knowing
I should keep this but I do not require it
She is 50-70 years young and in excellent condition for her age
Comes with some shells and the sling that is era matching and been on her since day one
$1k flat nothing less and no trades needed
Picked this up hoping to tinker with it and make it a beater home defense or trunk gun.
It has a feed/ejection problem and I’ve not had the time to fully troubleshoot it. Load a shell, it fires. Rack it back and sometimes the empty ejects and sometimes it doesn’t, which of...
No trades, no low-ball offers.
This is a factory barrel. Has seen light use. Looks new.
Retail on these is stupid. Like $200.
28" Vent rib barrel with dual bead - Accuchoke - Blued.
Thanks for looking.